Bibigul Ilyassova
Syzganov national Scientific Center of Surgery,Kazakhstan
Title: The changes of cytokines levels in progression of liver fibrosis caused by HDV-infection
Biography
Biography: Bibigul Ilyassova
Abstract
Cirrhosis in the outcome of chronic hepatitis D (CHD) is the most common cause of liver transplantation in Kazakhstan . The CHD is an immune-mediated disease The aim of the study was to determine the role of cytokines in the progression of liver fibrosis in chronic hepatitis D
A total of 105 patients with CHD and cirrhosis caused by HDV-infection were examined. We uses ELISA tests and Fibroscan 502
The results showed the level of cytokines increase of TNF-α (P =0.009), IL-10 (P=0.002), depending on the stage of fibrosis. TNFα has a positive correlation with ALT (r =0.358, P<0.0001), AST (r=0.452, P<0.0001) and negative with creatinine ​​(r=-0.396, P=0.002), urea (r=-0.280, P=0.019), platelets (r=-0.290, P=0.005); and leukocytes (r=-0.342, P = 0.001). IL-10 has a positive correlation with ALT (r=0.256, P=0.004), AST (r=0.380, P<0.0001), bilirubin (r=0.194, P=0.037 ), and negative with albumin ​​(r=-0.586, P=0.005), creatinine (r=-0.389, P=0.003), urea (r=-0.267,P=0.026), platelets (r=-0.379, P<0.0001); and leukocytes (r=-0.382, P<0.0001). IL-17 has negative relationship with ALT and AST (r=-0.209, P=0.021 and r=-0.249, P=0.006).TGFβ1 has a positive relationship with ALT (r=0,263, P = 0,014), AST (r=0,263, P=0,004), albumin (r=0,600, P=0,004), total protein (r=0,296,P=0,027), TNFα (r=0,897, P<0.0001), IL-10 (r = 0.665, P <0.0001), and negative with IL-17 (r=-0.677, P <0.0001) and creatinine (r=-0.354, P=0.014).
Conclusion: CHD progression is associated with the activity of the of TNF-α and IL-10, which have a negative relationship with IL-17 and positive with TGFβ1. The initiation of autoimmune inflammation occurs in the early stages fibrosis and in cirrhosis occurs decrese of autoimmune inflammation